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Documented Research

The information provided by Live Cell Research is based purely on documented research. Below you can read the verified research behind Niagen™.

All research listed below have citations or actual links to clinical studies, so you can verify the information yourself.

Mitochondrial Function
Cell: Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
Findings: Raising NAD+ levels in old mice reverses metabolic dysfunction and restores mitochondrial function to that of a young mouse.
(Link To Research)  

Trends in Cell Biology: NAD+ and sirtuins in aging and disease.
Findings: Restoring NAD+ by supplementing NAD+ intermediaries dramatically ameliorates age-associated defects, counteracting many diseases of aging.
(Link To Research)  

Cell Metabolism: NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease.
Findings: NR supplementation led to marked improvement of certain mitochondrial disease in mice, and could potentially be successful in humans as well.
(Link To Research)  

EMBO Molecular Medicine: Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3.
Findings: NR effectively delayed early- and late-stage mitochondrial disease progression in mice.
(Link To Research)  

Cell Metabolism: The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
Findings: NR supplementation in mammalian cells increases NAD+ levels, culminating in protection against hgh-fat diet-induced metabolic abnormalities.
(Link To Research)  

Cognitive Function
Neurobiology of Aging: Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models.
Findings: NR treatment might benefit Alzheimer’s disease cognitive function and synaptic plasticity
(Link To Research)  

The Journal of Neuroscience: Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy
Findings: Stimulation of NAD pathways may be useful in preventing or delaying axonal degeneration, which occurs in many neurodegenerative diseases and after traumatic injury.
(Link To Research)  

PLOS Biology: NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy.
Findings: Increasing NAD+ levels with NR ameliorates muscular dystrophy in zebrafish.
(Link To Research)  

Cell Metabolism: Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.
Findings: Increasing NAD+ levels ameliorated Type 2 diabetes symptoms in mice.
(Link To Research)  

NAD+ Biosynthesis
The Journal of Biological Chemistry: Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae.
Findings: A balanced NR salvage cycle is essential for calorie restriction-induced life span extension and stress resistance in yeast.
(Link To Research)  

The Journal of Biological Chemistry: Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism.
Findings: NR elevates NAD+ levels and extends replicative lifespan in yeast.
(Link To Research)  

PLOS Biology: Nicotinamide riboside kinase structures reveal new pathways to NAD+.
Findings: NR led to the identification of new pathways to NAD+ in yeast.
(Link To Research)  

Cell: Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.
Findings: NR extends lifespan without calorie restriction in yeast.
(Link To Research)  

Cell: Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans.
Findings: NR is a useful compound for elevation of NAD+ levels in humans.
(Link To Research)  

Cell: The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.
Findings: Restoration of NAD+ prevents age-associated metabolic decline and promotes longevity in worms.
(Link To Research)  

Cold Spring Harbor Symposia on Quantitative Biology: NAD+ as a signaling molecule modulating metabolism.
Findings: NAD+ has been identified as having a pivotal role in the control of whole-body metabolic homeostasis.
(Link To Research)  

Critical Reviews in Biochemistry and Molecular Biology: NAD+ metabolism: a therapeutic target for age-related metabolic disease.
Findings: Boosting NAD+ levels is a powerful means to activate sirtuins as a potential therapy for mitochondrial, often age-related diseases.
(Link To Research)  

Current Opinion in Clinical Nutrition and Metabolic Care: Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection.
Findings: NR has properties that are insulin sensitizing, enhancing to exercise, resisting to negative effects of high-fat diet, and neuroprotecting.
(Link To Research)  

Annual Review of Nutrition: Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition.
Findings: NR may be the only vitamin precursor that supports neuronal NAD+ synthesis.
(Link To Research)  

Journal of Pharmacology and Experimental Therapeutics: NAD+ and vitamin B3: from metabolism to therapies.
Findings: Discusses NAD+ biosynthesis for treatment of human disorders and infections.
(Link To Research)  

Trends in Biochemical Sciences: NAD+ metabolism in health and disease.
Findings: NR might have advantages as a therapy to elevate NAD+ without inhibiting sirtuins or incurring the unpleasant side effects of nicotinic acid.
(Link To Research)